Welcome to EmethCRC !
Transcription factor (TF), as sequence-specific DNA-binding proteins, act typically through cis-regulatory elements (such as enhancer and promoter) to coordinate the transcription of target genes. Some core TFs driven enhancers by form interconnected feed-forward transcriptional circuitry dominating cell-type-specific gene-expression program. The core TFs and their interconnected auto-regulatory loops have been termed ‘core transcription regulatory circuitry??? (CRC). Herein, we identified cancer-specific CRCs driven by enhancer methylation (emCRCs) based on a computational framework. Subsequentlly, potential downstream genes and clinically actionable TFs were curated in the database.
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2021, CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.
Description
Super Enhancer (Methylation region)
Alterations between cancer and normal samples
Note:
P
-value was calculated by Mann Whitney U test.
Coupled associations in emCRC
Note:
P
-value and Rho was calculated by Spearman's correlation test.
Hallmark Gene
Cancer-related Gene
Drug Target
Overall survival rate (stratified by median of risk score of emCRC)
Note:
P
-value was calculated by log-rank test.
2021, CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.
2021, CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.
Super Enhancer Region
UCSC Genome Browser for Super Enhancer
2021, CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.
Enhancer methylation-driven core transcriptional regulatory circuitry in pan-cancer
Click here to download (EmethCRC.xlsx, 15KB)
Enhancer methylation profiles in pan-cancer (TCGA)
BRCA (BRCA_MethylProfile.txt.gz, 6.4MB)
COADREAD (COADREAD_MethylProfile.txt.gz, 2.5MB)
HNSC (HNSC_MethylProfile.txt.gz, 4.2MB)
KIRC (KIRC_MethylProfile.txt.gz, 3.5MB)
KIRP (KIRP_MethylProfile.txt.gz, 2.3MB)
LIHC (LIHC_MethylProfile.txt.gz, 3.1MB)
LUAD (LUAD_MethylProfile.txt.gz, 3.6MB)
LUSC (LUSC_MethylProfile.txt.gz, 3MB)
PRAD (PRAD_MethylProfile.txt.gz, 4MB)
THCA (THCA_MethylProfile.txt.gz, 4.1MB)
Downstream gene of emCRC
DownstreamGenes.txt (5.4MB)
Source code
Code in the analysis (893KB)
2021, CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.
